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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU6033685
VU6033685

Chemical Structure : VU6033685

CAS No.:

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VU6033685 (BI1752, BI-1752)

货号: PC-24064Not For Human Use, Lab Use Only.

VU6033685 (BI1752) is a potent, selective positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 1 (mGlu1) with EC50 of 39 nM, Emax=65% (human mGlu1), and EC50 of 107 nM, Emax=94%.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VU6033685 (BI1752) is a potent, selective positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 1 (mGlu1) with EC50 of 39 nM, Emax=65% (human mGlu1), and EC50 of 107 nM, Emax=94%.
VU6033685 displays no activity against mGlu2/3/4, and mGlu6/6/8 receptors (Ec50>10 uM).
VU6033685 (1-10 mg/kg, p.o.) reverses amphetamine-induced hyperlocomotion (AHL) in rats.
VU6033685 (1-30 mg/kg) reverses MK-801-induced disruption of novel object recognition in rats.

物理化学性质&存储条件

分子量 366.85
分子式 C20H19ClN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-chloro-N-((6-cyclopropyl-2-methylpyridin-3-yl)methyl)-5-(1H-pyrazol-1-yl)benzamide

参考文献

1. Reed CW, et al. ACS Chem Neurosci. 2025 Feb 5. doi: 10.1021/acschemneuro.5c00014.

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