VU6015929 | DDR1/2 inhibitor | Probechem Biochemicals

Chemical Structure : VU6015929

CAS No.: 2442597-56-8

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VU6015929 (VU 6015929)

货号: PC-72924Not For Human Use, Lab Use Only.

VU6015929 (VU 6015929) is a potent, selective, dual DDR1/2 inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5480	In stock
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生物&药学活性

VU6015929 (VU 6015929) is a potent, selective, dual DDR1/2 inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively.
VU6015929 displays low cytotoxicity, good kinome selectivity, and possessing an acceptable in vitro DMPK profile with good rodent in vivo pharmacokinetics.
VU6015929 blocks collagen I-induced DDR1 autophosphorylation in DDR1 expressing cells, also blocks collagen IV production in a DDR1 dependent manner.

物理化学性质&存储条件

分子量	485.443
分子式	C24H19F4N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-fluoro-3-(((5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methyl)amino)-N-(3-(trifluoromethoxy)phenyl)benzamide

参考文献

1. Jeffries DE, et al. ACS Med Chem Lett. 2019 Nov 25;11(1):29-33.

VU6015929 (VU 6015929)

生物&药学活性

物理化学性质&存储条件

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VU6015929 (VU 6015929)

生物&药学活性

物理化学性质&存储条件

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