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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU6012962
VU6012962

Chemical Structure : VU6012962

CAS No.: 2313526-86-0

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VU6012962 (VU-6012962, VU 6012962)

货号: PC-36001Not For Human Use, Lab Use Only.

VU6012962 (VU-6012962) is a potent, orally bioavailable and CNS penetrant mGlu7 negative allosteric modulator (NAM) with IC50 of 0.35 uM.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU6012962 (VU-6012962) is a potent, orally bioavailable and CNS penetrant mGlu7 negative allosteric modulator (NAM) with IC50 of 0.35 uM.
VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes and across large ancillary pharmacology panels.
VU6012962 decreases anxiety in the elevated zero maze (EZM) assay in mice.

物理化学性质&存储条件

分子量 448.402
分子式 C21H19F3N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide

参考文献

1. Reed CW, et al. J Med Chem. 2019 Jan 4. doi: 10.1021/acs.jmedchem.8b01810.

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