VU6010608 |CAS:2165325-42-6 Probechem Biochemicals

Chemical Structure : VU6010608

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VU6010608 (VU 6010608;VU-6010608)

货号: PC-60149Not For Human Use, Lab Use Only.

VU6010608 is a potent, highly selective, CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.76 uM.

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生物&药学活性

VU6010608 is a potent, highly selective, CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.76 uM.
VU6010608 shows no activity against mGlu1,2,3,4,5,6,8, as well as a penel of 68 GPCRs, ion channels and transporters (IC50>10 uM).
VU6010608 blocks long-term potentiation (LTP) at SC-CA1 synapses in mice brain slices induced by high frequency stimulation.

物理化学性质&存储条件

分子量	408.337
分子式	C18H15F3N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-3,4-dimethoxybenzamide

参考文献

1. Carson W. Reed, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1326-1330.

VU6010608 (VU 6010608;VU-6010608)

生物&药学活性

物理化学性质&存储条件

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VU6010608 (VU 6010608;VU-6010608)

生物&药学活性

物理化学性质&存储条件

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