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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU6004909
VU6004909

Chemical Structure : VU6004909

CAS No.: 1860797-76-7

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VU6004909

货号: PC-23781Not For Human Use, Lab Use Only.

VU6004909 is a selective, CNS penetrant metabotropic glutamate receptor subtype 1 (mGlu1) positive allosteric modulator (PAM) with EC50 of 25.7 nM and 31 nM for human and rat mGlu1 respectively.

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5 mg ￥880 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU6004909 is a selective, CNS penetrant metabotropic glutamate receptor subtype 1 (mGlu1) positive allosteric modulator (PAM) with EC50 of 25.7 nM and 31 nM for human and rat mGlu1 respectively.
VU6004909 reduces dorsolateral striatal dopamine (DA) release in vivo and displays antipsychotic efficacy.

物理化学性质&存储条件

分子量 378.36
分子式 C21H15FN2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Furancarboxamide, N-[4-(1,3-dihydro-5-methyl-1,3-dioxo-2H-isoindol-2-yl)-2-fluorophenyl]-3-methyl-

参考文献

1. Luessen DJ, et al. Neuropsychopharmacology. 2022 Sep;47(10):1826-1835.

2. Garcia-Barrantes PM, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):751-756.

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