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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU6001966
VU6001966

Chemical Structure : VU6001966

CAS No.: 2009052-76-8

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VU6001966 (VU-6001966)

货号: PC-60939Not For Human Use, Lab Use Only.

VU 6001966 is a potent and selective, CNS penetrant mGlu2 negative allosteric modulator with IC50 of 78 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    VU 6001966 is a potent and selective, CNS penetrant mGlu2 negative allosteric modulator with IC50 of 78 nM.
    VU 6001966 shows no inhibition for mGlu3 (IC50>30 uM).
    VU 6001966 represents an exciting lead series for potential mGlu2 PET tracer development.

    物理化学性质&存储条件

    分子量 326.331
    分子式 C17H15FN4O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide

    参考文献

    1. Bollinger KA, et al. ACS Med Chem Lett. 2017 Aug 3;8(9):919-924.

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