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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU6001376
VU6001376

Chemical Structure : VU6001376

CAS No.: 1968546-34-0

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VU6001376 (VU 6001376, VU-6001376)

货号: PC-35690Not For Human Use, Lab Use Only.

VU6001376 (VU 6001376, VU-6001376) is a potent, selective, positive allosteric modulator of mGlu4 with EC50 of 28 nM, 49% Glu Max, shows no activity against other 7 mGlu receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    VU6001376 (VU 6001376, VU-6001376) is a potent, selective, positive allosteric modulator of mGlu4 with EC50 of 28 nM, 49% Glu Max, shows no activity against other 7 mGlu receptors.
    VU6001376 demonstrates efficacy in reversing haloperidol induced catalepsy in a rodent preclinical model of Parkinson's disease.

    物理化学性质&存储条件

    分子量 400.408
    分子式 C18H14F2N6OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-((1H-pyrazolo[4,3-b]pyridin-3-yl)amino)-N-(3,3-difluorocyclobutyl)benzo[d]isothiazole-3-carboxamide

    参考文献

    1. Bollinger S, et al. J Med Chem. 2018 Sep 24. doi: 10.1021/acs.jmedchem.8b00994.

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