VU6001221 | Choline transporter inhibitor | Probechem Biochemicals

Chemical Structure : VU6001221

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VU6001221 (VU 6001221)

货号: PC-62786Not For Human Use, Lab Use Only.

VU6001221 is a potent choline transporter (CHT) inhibitor with IC50 of 270 nM.

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生物&药学活性

VU6001221 is a potent choline transporter (CHT) inhibitor with IC50 of 270 nM.
VU6001221 shows comparable potency for choline uptake inhibition as ML352, yet improved PK and CNS penetration.
VU6001221 elicits a dose-responsive increase in NOR, raises the possibility of agonism of synaptic α7 nicotinic ACh receptors by elevated extracellular choline.

物理化学性质&存储条件

分子量	391.89
分子式	C20H26ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 4-chloro-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3 -[(1-methyl-4-piperidinyl)oxy]-

参考文献

1. Bertron JL, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4637-40.

VU6001221 (VU 6001221)

生物&药学活性

物理化学性质&存储条件

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VU6001221 (VU 6001221)

生物&药学活性

物理化学性质&存储条件

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