VU590 dihydrochloride |CAS:1783987-83-6 Probechem Biochemicals

Chemical Structure : VU590 dihydrochloride

CAS No.: 1783987-83-6

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VU590 dihydrochloride (VU-590;VU 590)

货号: PC-60570Not For Human Use, Lab Use Only.

VU590 is the first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK.

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5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg	￥4980	In stock
100 mg		Get quote

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生物&药学活性

VU590 is the first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK.
VU590 also inhibits inwardly rectifying K+ channel Kir7.1 (IC50=5.6 uM), but has no activity for Kir2.1 or Kir4.1.
VU590 induces profound, long-lasting contractions in mouse and human myometrium.

物理化学性质&存储条件

分子量	561.46
分子式	C24H32N4O7.2HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride

参考文献

1. Lewis LM, et al. Mol Pharmacol. 2009 Nov;76(5):1094-103.

2. Bhave G, et al. Mol Pharmacol. 2011 Jan;79(1):42-50.

3. McCloskey C, et al. EMBO Mol Med. 2014 Sep;6(9):1161-74.

4. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346.

VU590 dihydrochloride (VU-590;VU 590)

生物&药学活性

物理化学性质&存储条件

参考文献

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VU590 dihydrochloride (VU-590;VU 590)

生物&药学活性

物理化学性质&存储条件

参考文献

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