VU0606170 | KNa1.1 inhibitor | Probechem Biochemicals

Chemical Structure : VU0606170

CAS No.: 879054-55-4

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VU0606170 (VU 0606170)

货号: PC-73240Not For Human Use, Lab Use Only.

VU 0606170 is a selective sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) inhibitor with EC50 of 1.84 and 1.16 uM for WT Slack and A934T Slack, repectively.

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2 mg	￥2280	In stock
5 mg	￥3780	In stock
10 mg	￥5780	In stock
25 mg	￥9580	In stock
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100 mg		Get quote

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生物&药学活性

VU 0606170 is a selective sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) inhibitor with EC50 of 1.84 and 1.16 uM for WT Slack and A934T Slack, repectively.
VU0606170 did not modulate HEK293 channels expressing Slick, Slo1 α1/β1, Slo1 α1/β2, Slo1 α1/β3, Slo1 α1/β4, or Slo3 channels. also potently inhibits G288S and R428Q Slack channels.
VU0606170 also proved effective at significantly decreasing the firing rate in overexcited, spontaneously firing cortical neuron cultures.

物理化学性质&存储条件

分子量	444.975
分子式	C19H29ClN4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-chloro-2-methoxyphenyl)-2-(4-((4-methylpiperidin-1-yl)sulfonyl)piperazin-1-yl)acetamide

参考文献

1. Brittany D Spitznagel, et al. ACS Chem Neurosci. 2020 Nov 4;11(21):3658-3671.

VU0606170 (VU 0606170)

生物&药学活性

物理化学性质&存储条件

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VU0606170 (VU 0606170)

生物&药学活性

物理化学性质&存储条件

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