VU0546110 | Sperm SLO3 channel inhibitor | Probechem Biochemicals

Chemical Structure : VU0546110

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VU0546110 (VU 0546110)

货号: PC-49848Not For Human Use, Lab Use Only.

VU0546110 (VU 0546110) is a potent, selective inhibitor of the sperm-specific potassium channel SLO3 with IC50 of 1.29 uM, impairs sperm function.

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生物&药学活性

VU0546110 (VU 0546110) is a potent, selective inhibitor of the sperm-specific potassium channel SLO3 with IC50 of 1.29 uM, impairs sperm function.
VU0546110 could completely block heterologous SLO3 currents and endogenous K+ currents in human sperm.
VU0546110 prevented sperm from hyperpolarizing and undergoing hyperactivated motility and induced acrosome reaction, which are necessary to fertilize an egg.
SLO3 is the sole K+ channel responsible for hyperpolarization and significantly contributes to the fertilizing ability of human sperm.

物理化学性质&存储条件

分子量	461.64
分子式	C24H31NO4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(isopropylsulfonyl)phenyl)-1-(4-(((4-methoxyphenyl)thio)methyl)piperidin-1-yl)ethan-1-one

参考文献

1. Lyon M, et al. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2212338120.

VU0546110 (VU 0546110)

生物&药学活性

物理化学性质&存储条件

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VU0546110 (VU 0546110)

生物&药学活性

物理化学性质&存储条件

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