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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-VU0542270
VU0542270

Chemical Structure : VU0542270

CAS No.: 1396814-79-1

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VU0542270 (VU 0542270)

货号: PC-21733Not For Human Use, Lab Use Only.

VU0542270 is the first selective inhibitor of vascular Kir6.1/SUR2B KATP channel with IC50 of 129 nM, >300-fold selective over other members of the Kir channel family.

规格 价格 库存 数量
5 mg ￥3880 In stock
10 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU0542270 is the first selective inhibitor of vascular Kir6.1/SUR2B KATP channel with IC50 of 129 nM, >300-fold selective over other members of the Kir channel family.
VU0542270 (3 uM) inhibits both Kir6.1- or Kir6.2-containing channels in complex with either SUR2A or SUR2B, but not channels containing SUR1.
VU0542270 shows substantially blunted vasoconstrictive effects, induces ductus arteriosus (DA) constriction in a dose-dependent manner in on isolated mouse DA vessels.

物理化学性质&存储条件

分子量 335.46
分子式 C14H13N3OS3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-((4-methyl-2-(thiophen-2-yl)thiazol-5-yl)methyl)-3-(thiophen-2-yl)urea

参考文献

1. Li K, et al. Mol Pharmacol. 2024 Feb 1:MOLPHARM-AR-2023-000783.

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