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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU0486321
VU0486321

Chemical Structure : VU0486321

CAS No.: 1816301-67-3

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VU0486321

货号: PC-23779Not For Human Use, Lab Use Only.

VU0486321 is a potent, selective metabotropic glutamate receptor subtype 1 (mGlu1, mGluR1) positive allosteric modulator (PAM) with EC50 of 31.87 nM (human Glu1), 35-fold selective over mGlu4.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VU0486321 is a potent, selective metabotropic glutamate receptor subtype 1 (mGlu1, mGluR1) positive allosteric modulator (PAM) with EC50 of 31.87 nM (human Glu1), 35-fold selective over mGlu4.

物理化学性质&存储条件

分子量 398.77
分子式 C20H12ClFN2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Furancarboxamide, N-[3-chloro-4-(4-fluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-3-methyl-

参考文献

1. Garcia-Barrantes PM, et al. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5107-10.

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