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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU0463597
VU0463597

Chemical Structure : VU0463597

CAS No.: 1382481-79-9

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VU0463597 (ML289)

货号: PC-22906Not For Human Use, Lab Use Only.

ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 with IC50 of 0.66 uM, shows >15-fold selectivity over mGlu2 and is inactive against mGlu5.

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10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 with IC50 of 0.66 uM, shows >15-fold selectivity over mGlu2 and is inactive against mGlu5.

物理化学性质&存储条件

分子量 349.43
分子式 C22H23NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[(3R)-3-(Hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone

参考文献

1. Douglas J Sheffler, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3921-5.

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