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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Chloride Channel-VU 0463271
VU 0463271

Chemical Structure : VU 0463271

CAS No.: 1391737-01-1

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VU 0463271 (VU0463271)

货号: PC-62063Not For Human Use, Lab Use Only.

VU 0463271 is a potent, selecitve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 61 nM.

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10 mg ￥1480 In stock
25 mg ￥2680 In stock
50 mg ￥4580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU 0463271 is a potent, selecitve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 61 nM.
VU 0463271 displays >100-fold selectivity versus NKCC1 (>100 uM), no significant activities on a panel of 68 GPCRs, ion channels and transporters.
VU 0463271 exhibts 9-times more potent than ML077, and maintains an excellent ancillary pharmacology profile.

物理化学性质&存储条件

分子量 382.5
分子式 C19H18N4OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

参考文献

1. Delpire E, et al. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8.

2. Delpire E, et al. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5.

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