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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU0424465
VU0424465

Chemical Structure : VU0424465

CAS No.: 1428630-85-6

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VU0424465 (ML273)

货号: PC-27667Not For Human Use, Lab Use Only.

VU0424465 (ML273) is a potent, selective agonist/positive allosteric modulator (ago-PAM) of mGlu5 receptor with radioligand binding IC50 of 7.3 nM and EC50 of 9.4 nM.

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5 mg ￥1480 In stock
10 mg ￥2180 In stock
25 mg ￥3580 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU0424465 (ML273) is a potent, selective agonist/positive allosteric modulator (ago-PAM) of mGlu5 receptor with radioligand binding IC50 of 7.3 nM and EC50 of 9.4 nM.
VU0424465 exhibits high affinity at MPEP allosteric binding site with Ki of 11.8 nM.

物理化学性质&存储条件

分子量 326.37
分子式 C19H19FN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-5-((3-Fluorophenyl)ethynyl)-N-(3-hydroxy-3-methylbutan-2-yl)picolinamide

参考文献

1. Manka J, et al. 2011 Dec 16 [updated 2013 Mar 7]. In: Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Hellyer SD, et al. J Neurochem. 2019 Nov;151(3):301-315.

3. Nasrallah C, et al. Sci Rep. 2018 Mar 13;8(1):4407.

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