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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU0418506
VU0418506

Chemical Structure : VU0418506

CAS No.: 1330624-42-4

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VU0418506 (VU 0418506)

货号: PC-35487Not For Human Use, Lab Use Only.

VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4).
    VU0418506 displays selectivity versus the Group I and Group II mGlu receptors and against mGlu7 and mGlu8.
    VU0418506 does not potentiate agonist-induced activity when mGlu2 and mGlu4 are heterodimerized; VU0418506 is clean against a panel of ion channels associated with cardiac toxicity and it negative in a mini-AMES assay with and without S9.

    物理化学性质&存储条件

    分子量 262.67
    分子式 C12H8ClFN4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine

    参考文献

    1. Engers DW, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1192-200.

    2. Niswender CM, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1201-11.

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