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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU0360172
VU0360172

Chemical Structure : VU0360172

CAS No.: 1310012-12-4

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VU0360172 (VU 0360172)

货号: PC-49074Not For Human Use, Lab Use Only.

VU0360172 is a selective mGlu5 receptor positive allosteric modulator (PAM) with EC50 of 16 nM, Ki of 195 nM.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU0360172 is a selective mGlu5 receptor positive allosteric modulator (PAM) with EC50 of 16 nM, Ki of 195 nM.
VU0360172 displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors.
VU0360172 exhibits antipsychotic-like activity in a rodent model, also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

物理化学性质&存储条件

分子量 294.329
分子式 C18H15FN2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide

参考文献

1. Celli R, et al. Neuropharmacology. 2020 Nov 1;178:108240.

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