Chemical Structure : VU 0240551
CAS No.: 893990-34-6
货号: PC-62064Not For Human Use, Lab Use Only.
VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.
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5 mg | ¥980 | In stock | |
10 mg | ¥1380 | In stock | |
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50 mg | ¥3780 | In stock | |
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VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.
VU 0240551 displays >100-fold selectivity over NKCCl; also shows significant inhibition (>50% at 50 µM) of several GPCRs and key ion channels (hERG and L-Type Ca2+ channels).
分子量 | 342.43 | |
分子式 | C16H14N4OS2 | |
外观性状 | Solid | |
储存条件 |
|
|
Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide |
1. Deisz RA, et al. Neuroscience. 2014 Sep 26;277:831-41.
2. Chevy Q, et al. J Neurosci. 2015 Dec 2;35(48):15772-86.
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