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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-VU 0240551
VU 0240551

Chemical Structure : VU 0240551

CAS No.: 893990-34-6

VU 0240551 (VU0240551)

货号: PC-62064Not For Human Use, Lab Use Only.

VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.
VU 0240551 displays >100-fold selectivity over NKCCl; also shows significant inhibition (>50% at 50 µM) of several GPCRs and key ion channels (hERG and L-Type Ca2+ channels).

物理化学性质&存储条件

分子量 342.43
分子式 C16H14N4OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

参考文献

1. Deisz RA, et al. Neuroscience. 2014 Sep 26;277:831-41.

2. Chevy Q, et al. J Neurosci. 2015 Dec 2;35(48):15772-86.

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