VU0155041 | mGluR4 PAM | Probechem Biochemicals

Chemical Structure : VU0155041

CAS No.: 1093757-42-6

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VU0155041 (VU 0155041)

货号: PC-22230Not For Human Use, Lab Use Only.

VU0155041 is a potent, selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 798 and 693 nM at human and rat mGluR4, respectively.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

VU0155041 is a potent, selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 798 and 693 nM at human and rat mGluR4, respectively.
VU0155041 is a partial agonist of mGluR4 that activates the receptor by interacting with a site that is distinct from the glutamate binding site.
VU0155041 does not antagonize NMDA receptors, also has no effect on binding for 67 different targets including GPCRs, ion channels, and transporters.
VU0155041 has antiparkinsonian effects in preclinical rodent models of PD, reverses reserpine-induced akinesia in rats.

物理化学性质&存储条件

分子量	316.18
分子式	C14H15Cl2NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-(1R,2S)-2-((3,5-Dichlorophenyl)carbamoyl)cyclohexane-1-carboxylic acid

参考文献

1. Niswender CM, et al. Mol Pharmacol. 2008 Nov;74(5):1345-58.

VU0155041 (VU 0155041)

生物&药学活性

物理化学性质&存储条件

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VU0155041 (VU 0155041)

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物理化学性质&存储条件

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