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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-VU0071063
VU0071063

Chemical Structure : VU0071063

CAS No.: 333415-38-6

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VU0071063 (VU 0071063)

货号: PC-21735Not For Human Use, Lab Use Only.

VU0071063 is a potent and specific Kir6.2/SUR1 opener with EC50 of 7.44 uM, inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU0071063 is a potent and specific Kir6.2/SUR1 opener with EC50 of 7.44 uM, inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential.
VU0071063 dose dependently opens Kir6.2/SUR1, inhibits glucose-stimulated insulin secretion.
VU0071063 dose dependently and reversibly hyperpolarizes the β-cell membrane potential, inhibits glucose-stimulated Ca2+ entry and insulin secretion.
VU0071063 significant increases blood glucose in vivo.

物理化学性质&存储条件

分子量 326.40
分子式 C18H22N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-(4-(tert-Butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

参考文献

1. Kharade SV, et al. J Pharmacol Exp Ther. 2019;370(3):350-359.

2. Raphemot R, et al. Mol Pharmacol. 2014;85(6):858-865.

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