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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU-29
VU-29

Chemical Structure : VU-29

CAS No.: 890764-36-0

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VU-29 (VU29, DPAP)

货号: PC-62953Not For Human Use, Lab Use Only.

VU-29 (DPAP) is a potent, selective and allosteric potentiator of rat mGlu5 receptor with EC50 of 9 nM, displays >50-fold selectivity over mGlu1 and mGlu2 receptor (EC50=557 nM and 1.51 uM).

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25 mg ￥2280 In stock
50 mg ￥3680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU-29 (DPAP) is a potent, selective and allosteric potentiator of rat mGlu5 receptor with EC50 of 9 nM, displays >50-fold selectivity over mGlu1 and mGlu2 receptor (EC50=557 nM and 1.51 uM).
VU-29 (DPAP) potentiates both DHPG-induced LTP and threshold θ-burst stimulation (TBS)-induced LTP in rat hippocampal slices.

物理化学性质&存储条件

分子量 384.395
分子式 C22H16N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide

参考文献

1. Chen Y, et al. Mol Pharmacol. 2007 May;71(5):1389-98.

2. de Paulis T, et al. J Med Chem. 2006 Jun 1;49(11):3332-44.

3. Ayala JE, et al. Neuropsychopharmacology. 2009 Aug;34(9):2057-71.

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