VTP-27999 TFA | Renin inhibitor | Probechem Biochemicals

Chemical Structure : VTP-27999 TFA

CAS No.: 1013937-63-7

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VTP-27999 TFA (VTP27999 TFA, VTP 27999)

货号: PC-45865Not For Human Use, Lab Use Only.

VTP-27999 TFA is a potent, highly selective renin inhibitor with IC50 of 0.47 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

VTP-27999 TFA is a potent, highly selective renin inhibitor with IC50 of 0.47 nM.
VTP-27999 displays >1000-fold selectivity for renin over a panel of >150 receptors, ion channels, and enzymes, and has an IC50 value >30 uM against CYP3A4.
VTP-27999 demonstrates >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans.

物理化学性质&存储条件

分子量	639.1039
分子式	C28H42ClF3N4O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Carbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester, 2,2,2-trifluoroacetate (1:1)

参考文献

1. Jia L, et al. ACS Med Chem Lett. 2011 Aug 9;2(10):747-51.

2. Krop M, et al. Hypertension. 2013 May;61(5):1075-82.

3. Balcarek J, et al. Hypertension. 2014 May;63(5):942-50.

VTP-27999 TFA (VTP27999 TFA, VTP 27999)

生物&药学活性

物理化学性质&存储条件

参考文献

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VTP-27999 TFA (VTP27999 TFA, VTP 27999)

生物&药学活性

物理化学性质&存储条件

参考文献

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