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首页-小分子抑制剂&激动剂-Others-Other Targets-VTI-1002
VTI-1002

Chemical Structure : VTI-1002

CAS No.:

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VTI-1002 (VTI1002)

货号: PC-35175Not For Human Use, Lab Use Only.

VTI-1002 is a first-in-class, highly potent, selective inhibitor of human Granzyme B (GzmB) with Ki of 4.4 nM, exhibits strong selectivity for GzmB over caspases 3-10, cathepsin G, and neutrophil elastase.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    VTI-1002 is a first-in-class, highly potent, selective inhibitor of human Granzyme B (GzmB) with Ki of 4.4 nM, exhibits strong selectivity for GzmB over caspases 3-10, cathepsin G, and neutrophil elastase.
    VTI-1002 is nearly 20 times more potent against human GzmB than Ac-IEPD-CHO (Ki=80 nM), exhibits potent inhibition against mouse GzmB (IC50=179 nM).
    VTI-1002 improves remodeling in a murine model of impaired burn wound healing.

    物理化学性质&存储条件

    分子量
    分子式
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    参考文献

    1. Shen Y, et al. Exp Mol Med. 2018 May 30;50(5):68.

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