VT107 (VT-107)

Chemical Structure : VT107

CAS No.: 2417718-63-7

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货号: PC-72507Not For Human Use, Lab Use Only.

VT107 (VT-107) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 4.93 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

VT107 (VT-107) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 4.93 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor.
VT107 inhibited palmitoylation of both endogenous TEAD1, TEAD3, and TEAD4 proteins in cells.
VT107 decreased the levels of palmitoylated TEAD3 and TEAD4 and increased the levels of unpalmitoylated TEAD3 and TEAD4 in the human mesothelioma cell line NCI-H2373.
VT107 blocked YAP and TAZ interaction with both TEAD1 and TEAD4.
VT107 exhibited inhibitory activity in more mesothelioma cell lines than the TEAD1-selective inhibitor VT103.

物理化学性质&存储条件

分子量	435.45
分子式	C25H20F3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1S)-1-(6-Amino-2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide

参考文献

1. Tracy T Tang, et al. Mol Cancer Ther. 2021 Jun;20(6):986-998.

VT107 (VT-107)

生物&药学活性

物理化学性质&存储条件

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VT107 (VT-107)

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