VT104 (VT-104)

Chemical Structure : VT104

CAS No.: 2417718-25-1

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货号: PC-72508Not For Human Use, Lab Use Only.

VT104 (VT-104) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 10.4 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

VT104 (VT-104) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 10.4 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor.
VT104 inhibited palmitoylation of both endogenous TEAD1, TEAD3 proteins in cells.
VT104 decreased the levels of palmitoylated TEAD3 and TEAD4 and increased the levels of unpalmitoylated TEAD3 and TEAD4 in the human mesothelioma cell line NCI-H2373.VT104 exhibited inhibitory activity in more mesothelioma cell lines than the TEAD1-selective inhibitor VT103.
VT104 (oral administration of 10 and 3 mg/kg) has very strong antitumor efficacy in the human mesothelioma NCI-H226 CDX model, with no effect on body weight gain.

物理化学性质&存储条件

分子量	420.435
分子式	C25H19F3N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1S)-1-(2-Pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide

参考文献

1. Tracy T Tang, et al. Mol Cancer Ther. 2021 Jun;20(6):986-998.

VT104 (VT-104)

生物&药学活性

物理化学性质&存储条件

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VT104 (VT-104)

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