VT02956 | Probechem Biochemicals

Chemical Structure : VT02956

CAS No.: 2999763-09-4

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VT02956 (VT 02956)

货号: PC-38110Not For Human Use, Lab Use Only.

VT02956 is a potent, specific inhibitor of Hippo pathway kinase LATS with IC50 of 0.76 nM (LATS1) and 0.52 nM (LATS2), respectively.

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10 mg	￥5780	In stock
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生物&药学活性

VT02956 is a potent, specific inhibitor of Hippo pathway kinase LATS with IC50 of 0.76 nM (LATS1) and 0.52 nM (LATS2), respectively.
VT02956 reduces YAP/TAZ phosphorylation in both dose- and time-dependent manner with IC50 of 0.16 μM and 0.43 μM in HEK293A cells and 4T1 cells, respectively.
VT02956 suppresses ESR1 transcription, dramaticly reduces ERα and its target genes TFF1 and GREB1.
VT02956 targets the LATS-YAP/TAZ-ERα axis to inhibit ER+ tumours cell growth, inhibits the proliferation of MCF-7 and T47D cells.
VT02956 inhibits the growth of T47D cells with hormone therapy resistant ESR1 mutation (ERa Y537S or D538G), enhances the anti-tumour effect of palbociclib in ER+ breast cancer cells.

物理化学性质&存储条件

分子量	373.46
分子式	C22H23N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(4-(aminomethyl)piperidin-1-yl)-2-(pyridin-4-yl)quinazolin-8-yl)prop-2-yn-1-ol

参考文献

1. Shenghong Ma, et al. Nat Commun. 2022 Feb 25;13(1):1061.

VT02956 (VT 02956)

生物&药学活性

物理化学性质&存储条件

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VT02956 (VT 02956)

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