VS-II-173 |CAS:1627962-21-3 Probechem Biochemicals

Chemical Structure : VS-II-173

加入收藏

VS-II-173 (Pim1/Pim3 inhibitor)

货号: PC-36029Not For Human Use, Lab Use Only.

VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell).
VS-II-173 acts synergistically with the anthracycline daunorubicin, and additively with a number of other anti-cancer drugs.
VS-II-173 attenuates phosphorylation of Pim kinase substrates, shows towards cell lines harboring the FLT3-ITD mutation (Molm-13, FLT3-ITD heterozygous and MV4-11 FLT3-ITD homozygous) with EC50 of 2-3 uM.
VS-II-173 also induces cell death also in AML patient blasts, including blast carrying high-risk FLT3-ITD mutation.

物理化学性质&存储条件

分子量	264.244
分子式	C14H8N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-nitro-3H-pyrazolo[4,3-a]phenanthridine

参考文献

1. Suchaud V, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4704-10.

2. Bjørnstad R, et al. Mol Cancer Ther. 2019 Jan 24. pii: molcanther.1234.2017. doi: 10.1158/1535-7163.MCT-17-1234.

VS-II-173 (Pim1/Pim3 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

VS-II-173 (Pim1/Pim3 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.