VS-186B | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : VS-186B

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VS-186B (VS186B)

货号: PC-26229Not For Human Use, Lab Use Only.

VS-186B is a small molecule HDAC inhibitor with IC50 of 2.5 uM, inhibits Class I and II HDACs in a dose-dependent manner.

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生物&药学活性

VS-186B is a small molecule HDAC inhibitor with IC50 of 2.5 uM, inhibits Class I and II HDACs in a dose-dependent manner.
VS-186B is very cytotoxic to multiple cancer cell lines, specifically hematological cell lines like Jurkat, displays the most potency towards Jurkat with a CC50 of 2.91 uM.
VS-186B induces apoptosis through the intrinsic pathway in Jurkat cells, does not induce cell cycle arrest.
VS-186B induces apoptosis in cancer cells without significant cytotoxicity to non-cancerous lines with a similar gene expression profile to known HDAC inhibitors.

物理化学性质&存储条件

分子量	351.36
分子式	C20H17NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-hydroxy-4-((1E,3Z,6E)-3-hydroxy-7-(4-hydroxyphenyl)-5-oxohepta-1,3,6-trien-1-yl)benzamide

参考文献

1. Sanchez-Michael LA, et al. Int J Mol Sci. 2025 Nov 24;26(23):11354.

2. Allison Elias, et al. Mol Cancer Ther (2025) 24 (10_Supplement): C030.

VS-186B (VS186B)

生物&药学活性

物理化学性质&存储条件

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VS-186B (VS186B)

生物&药学活性

物理化学性质&存储条件

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