VPS18 inhibitor RDN | VPS18 inhibitor | Probechem Biochemicals

Chemical Structure : VPS18 inhibitor RDN

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VPS18 inhibitor RDN (Riccardin D-N)

货号: PC-23220Not For Human Use, Lab Use Only.

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生物&药学活性

VPS18 inhibitor RDN is a specific lysosomotropic agent that targeting vacuole protein sorting 18 (VPS18), binds to the RING domain of VPS18, leading to disruption of the VPS-C core complex and lysosomal function.
VPS18 inhibitor RDN reverses TFE3-mediated drug resistance.
VPS18 inhibitor RDN impaired PD-L1 member trafficking and protein stability.
Combination treatment of RDN and anti-cytotoxic T lymphocyte–associated antigen 4 synergistically enhances antitumor efficacy in aggressive and drug-resistant tumors.

物理化学性质&存储条件

分子量	538.69
分子式	C34H38N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,6:15,18-Dietheno-8,12-metheno-12H-7-benzoxacycloeicosin-9,17,19-triol, 10,20-bis[(dimethylamino)methyl]-1,2,13,14-tetrahydro-

参考文献

1. Dong T, et al. Sci Adv. 2024 Oct 18;10(42):eadp4917.

2. H. Niu, et al. Signal Transduct. Target. Ther. 6, 224 (2021).

VPS18 inhibitor RDN (Riccardin D-N)

生物&药学活性

物理化学性质&存储条件

参考文献

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VPS18 inhibitor RDN (Riccardin D-N)

生物&药学活性

物理化学性质&存储条件

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