VPC285785 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : VPC285785

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VPC285785 (VPC-285785)

货号: PC-26027Not For Human Use, Lab Use Only.

VPC285785 is a novel covalent inhibitor of the SARS-CoV-2 main protease (Mpro) with IC50 of 0.8 uM, VPC285786 additionally inhibits human cathepsin Lwith IC50 of 4.2 uM.

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生物&药学活性

VPC285785 is a novel covalent inhibitor of the SARS-CoV-2 main protease (Mpro) with IC50 of 0.8 uM, VPC285786 additionally inhibits human cathepsin Lwith IC50 of 4.2 uM.
VPC285785 significantly reduced viral load in liver, brain, and spleen tissues compared to vehicle- and Nirmatrelvir-treated controls.

物理化学性质&存储条件

分子量	469.49
分子式	C24H25F2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-(4,6-difluoro-1H-indole-2-carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

参考文献

1. Jason R Smith, et al. Sci Rep. 2026 Feb 2. doi: 10.1038/s41598-026-36842-2.

VPC285785 (VPC-285785)

生物&药学活性

物理化学性质&存储条件

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VPC285785 (VPC-285785)

生物&药学活性

物理化学性质&存储条件

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