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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-VPC01091.4
VPC01091.4

Chemical Structure : VPC01091.4

CAS No.: 945604-76-2

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VPC01091.4

货号: PC-21130Not For Human Use, Lab Use Only.

VPC01091.4 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 0.665 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    VPC01091.4 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 0.665 uM.
    VPC01091.4 inhibit LPS-induced inflammatory gene expression in macrophages and microglia.
    VPC01091.4 reduces systemic peripheral inflammation in a mouse model of LPS-induced endotoxemia.
    VPC01091.4 blunts brain and lung inflammation in the mouse model of endotoxemia.

    物理化学性质&存储条件

    分子量 303.49
    分子式 C20H33NO
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1S,3R)-1-Amino-3-(4-octylphenyl)cyclopentanemethanol

    参考文献

    1. Busey GW, et al. J Gen Physiol. 2024 Jan 1;156(1):e202313419.

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