VPC-260724 | ER-AF2 inhibitor | Probechem Biochemicals

Chemical Structure : VPC-260724

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VPC-260724 (VPC260724)

货号: PC-23562Not For Human Use, Lab Use Only.

VPC-260724 is a specific small molecule inhibitor of estrogen receptor-activation function 2 (ER-AF2) with IC50 of 5.7 uM for inhibition of ER transcription in T47D-KBluc cells.

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生物&药学活性

VPC-260724 is a specific small molecule inhibitor of estrogen receptor-activation function 2 (ER-AF2) with IC50 of 5.7 uM for inhibition of ER transcription in T47D-KBluc cells.
VPC-260724 reduces viability in ER-positive T47D and MCF7, the ER-positive and tamoxifen-resistant TamR3 cell line with IC50 of 7.4 uM.
VPC-260724 does not significantly impact the transcriptional activities of AR, GR, or PR
VPC-260724 (10 uM, 48 h) significantly reduced ER-SRC3 interactions in both MCF7 and TamR3 cells.
VPC-260724 inhibits the growth of MCF7, and TamR3 spheroids with IC50 values of 15.6 ± 1.4 µM and 27.0 ± 3.2 µM, respectively.
VPC-260724 shows antiproliferative activity in ER-positive breast cancer models.

物理化学性质&存储条件

分子量	295.39
分子式	C17H21N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-dimethyl-6-((((8-methylimidazo[1,2-a]pyridin-3-yl)methyl)amino)methyl)pyridin-2-amine

参考文献

1. Foo J, et al. Breast Cancer Res. 2024 Nov 26;26(1):168.

VPC-260724 (VPC260724)

生物&药学活性

物理化学性质&存储条件

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VPC-260724 (VPC260724)

生物&药学活性

物理化学性质&存储条件

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