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首页-小分子抑制剂&激动剂-Others-Other Targets-VPC-18005
VPC-18005

Chemical Structure : VPC-18005

CAS No.: 2242480-48-2

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VPC-18005 (VPC18005)

货号: PC-61463Not For Human Use, Lab Use Only.

VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM).

规格 价格 库存 数量
5 mg ￥2480 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM).
VPC-18005 markedly decreases SOX9 expression, inhibits migration and invasion of ERG-overexpressing prostate cancer cells in vitro, and reduces metastasis in a zebrafish xenograft model.

物理化学性质&存储条件

分子量 319.379
分子式 C15H17N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((R,E)-2-(((E)-4-isopropylbenzylidene)hydrazono)-4-oxothiazolidin-5-yl)acetic acid

参考文献

1. Butler MS, et al. Oncotarget. 2017 Jun 27;8(26):42438-42454.

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