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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Androgen Receptor (AR)-VPC-13789
VPC-13789

Chemical Structure : VPC-13789

CAS No.: 2761146-51-2

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VPC-13789 (VPC13789)

货号: PC-72753Not For Human Use, Lab Use Only.

VPC-13789 (VPC13789) is a potent, selective, orally available inhibitor of androgen receptor binding function-3 (BF3) site with IC50 of 0.19 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VPC-13789 (VPC13789) is a potent, selective, orally available inhibitor of androgen receptor binding function-3 (BF3) site with IC50 of 0.19 uM.
VPC-13789 suppresses AR-mediated transcription, chromatin binding, and recruitment of coregulatory proteins.
VPC-13789 selectively reduces the growth of both androgen-dependent and enzalutamide-resistant PCa cell lines.
VPC-13789 demonstrated in vitro efficacy that reduced PSA production and tumor volume in animal models of CRPC with no observed toxicity.

物理化学性质&存储条件

分子量 383.37
分子式 C21H16F3N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-isopropyl-2-(5,6,7-trifluoro-1H-indol-3-yl)quinoline-5-carboxamide

参考文献

1. Eric Leblanc, et al. J. Med. Chem. 2021, 64, 20, 14968–14982.

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