VPAC2 antagonist 1

Chemical Structure : VPAC2 antagonist 1

加入收藏

货号: PC-20663Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

VPAC2 antagonist 1 is a small molecule human vsoactive intestinal peptide receptor-2 (hVIPR2, hVPAC2 receptor) antagonist, inhibits VPAC2-mediated cAMP accumulation with IC50 of 3.8 uM and the ligand-activated beta-arrestin2 binding with IC50 of 2.3 uM.
VPAC2 antagonist 1 is a specific VPAC2 antagonist with no detectable agonist or antagonist activities on VPAC(1) or PAC(1).
VPAC2 antagonist 1 is completely inactive on the closely related mouse VPAC2.
VPAC2 antagonist 1 is the first small molecular antagonist that is specific for VPAC(2), and the only VPAC(2) antagonist molecule known to date that allosterically interacts with the 7TM region.

物理化学性质&存储条件

分子量	539.60
分子式	C27H29N3O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N[C@@H]1[C@H](O)CC2=C1C=CC=C2)[C@H](CC3=CC=CC=C3)C[C@H](O)CNS(=O)(C4=CC=C([N+]([O-])=O)C=C4)=O

参考文献

1. Alan Chu, et al. Mol Pharmacol. 2010 Jan;77(1):95-101.