VP 21-04 | HO-1 inhibitor | Probechem Biochemicals

Chemical Structure : VP 21-04

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VP 21-04 (VP21-04)

货号: PC-23515Not For Human Use, Lab Use Only.

VP 21-04 is a potent, selective Heme oxygenase-1 (HO-1) inhibitor with IC50 of 0.9 uM, displays 42-fold selective over HO-2 (IC50=38 uM).

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生物&药学活性

VP 21-04 is a potent, selective Heme oxygenase-1 (HO-1) inhibitor with IC50 of 0.9 uM, displays 42-fold selective over HO-2 (IC50=38 uM).
VP 21-04 showed strong cytotoxic activity against melanoma and breast cancer cell lines.
VP21-04 exhibited cytotoxic activity towards SK-MEL-5 and MDA-MB-468 cell lines both overexpressing HO-1.
VP21-04 has been encapsulated in NLC to enhance its water solubility, and ADMET profile.

物理化学性质&存储条件

分子量	475.33
分子式	C21H22IN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(1H-imidazol-1-yl)butoxy)-N-benzyl-5-iodobenzamide

参考文献

1. Virzì NF, et al. Int J Pharm. 2024 Nov 23:124997.

VP 21-04 (VP21-04)

生物&药学活性

物理化学性质&存储条件

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VP 21-04 (VP21-04)

生物&药学活性

物理化学性质&存储条件

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