VP15 hydrochloride

Chemical Structure : VP15 hydrochloride

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货号: PC-49073Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

VP15 hydrochloride (VP-15 HCl) is a BBB-penetrant, orally active, multitarget directed ligand against acetylcholine and monoamine oxidase enzymes with IC50 of 0.04 and 0.37 uM for AChE and MAO-B, respectively, >600-fold selectivity over BuChE.
VP15 hydrochloride exhibited potent neuroprotective potential against 6-hydroxydopamine-induced neuronal damage in SH-SY5Y cells with up to 90% recovery.
VP15 hydrochloride significantly attenuated the spatial memory impairment and improved the cognitive deficits in the mice.
VP15 hydrochloride was an irreversible inhibitor and showed no cytotoxicity against neuronal cells.

物理化学性质&存储条件

分子量	464.010
分子式	C26H30ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-6-(2-(prop-2-yn-1-ylamino)phenyl)pyrimidin-2-amine hydrochloride

参考文献

1. Bhupinder Kumar, et al. ACS Chem. Neurosci. 2022.