VO-Ohpic trihydrate |CAS:476310-60-8 Probechem Biochemicals

Chemical Structure : VO-Ohpic trihydrate

CAS No.: 476310-60-8

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VO-Ohpic trihydrate (VO-Ohpic;VO Ohpic)

货号: PC-43375Not For Human Use, Lab Use Only.

VO-Ohpic trihydrate (VO-Ohpic) is a potent, selective and reversible PTEN inhibitor with IC50 of 35 nM in vitro.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

VO-Ohpic trihydrate (VO-Ohpic) is a potent, selective and reversible PTEN inhibitor with IC50 of 35 nM in vitro。
VO-Ohpic specifically inhibits PTEN’s cellular enzymatic activity, which in turn activates downstream targets such as Akt and FoxO3a, inhibits cell viability, cell proliferation and colony formation, and induces senescence-associated β-galactosidase activity in Hep3B cells (low PTEN expression)。
VO-Ohpic increases cellular PIP3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations。
VO-Ohpic decreases left ventricular systolic pressure and heart rate before ischemia in mice.

物理化学性质&存储条件

分子量	415.2032
分子式	C12H16N2O11V+
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO; H2O: < 0.1 mg/mL
Chemical Name/SMILES	Vanadate(1-), aqua(3-hydroxy-2-pyridinecarboxylato-κN1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxo-, hydrogen, trihydrate, (OC-6-45)- (9CI)

参考文献

1. Rosivatz E, et al. ACS Chem Biol. 2006 Dec 15;1(12):780-90.

2. Zu L, et al. Eur J Pharmacol. 2011 Jan 10;650(1):298-302.

3. Mak LH, et al. J Chem Biol. 2010 Oct;3(4):157-63.

4. Augello G, et al. Cell Cycle. 2016;15(4):573-83.

VO-Ohpic trihydrate (VO-Ohpic;VO Ohpic)

生物&药学活性

物理化学性质&存储条件

参考文献

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VO-Ohpic trihydrate (VO-Ohpic;VO Ohpic)

生物&药学活性

物理化学性质&存储条件

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