VMY-1-103 |CAS: 1209002-43-6 Probechem Biochemicals

Chemical Structure : VMY-1-103

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VMY-1-103 (VMY 1-103)

货号: PC-70177Not For Human Use, Lab Use Only.

VMY-1-103 is a dansylated analog of purvalanol B, and a CDK inhibitor that inhibits cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B.

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生物&药学活性

VMY-1-103 is a dansylated analog of purvalanol B, and a CDK inhibitor that inhibits cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B.
VMY-1-103 increases the sub G(1) fraction of apoptotic cells, induces PARP and caspase-3 cleavage and increases the levels of the death receptors DR4 and DR5, Bax and Bad.

物理化学性质&存储条件

分子量	708.27
分子式	C34H42ClN9O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Chloro-N-[2-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]ethyl]-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]benzamide

参考文献

1. Ringer L, et al. Cancer Biol Ther. 2011 Nov 1;12(9):818-26.

2. Sirajuddin P, et al. Cell Cycle. 2012 Oct 15;11(20):3801-9.

3. Waye S, et al. Aging (Albany NY). 2015 Oct;7(10):854-68.

VMY-1-103 (VMY 1-103)

生物&药学活性

物理化学性质&存储条件

参考文献

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VMY-1-103 (VMY 1-103)

生物&药学活性

物理化学性质&存储条件

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