欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-VLX600
VLX600

Chemical Structure : VLX600

CAS No.: 327031-55-0

加入收藏

VLX600 (VLX-600)

货号: PC-72445Not For Human Use, Lab Use Only.

VLX600 (VLX-600) is a small molecule iron chelator and mitochondrial oxidative phosphorylation (OXPHOS) inhibitor, targets quiescent tumor cells and to inhibit mitochondrial respiration.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥2180 In stock
100 mg ￥3580 In stock
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VLX600 (VLX-600) is a small molecule iron chelator and mitochondrial oxidative phosphorylation (OXPHOS) inhibitor, targets quiescent tumor cells and to inhibit mitochondrial respiration.
VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation, displays tumour growth inhibition in vivo. decrease mitochondrial energy production, an effect poorly tolerated by metabolically stressed tumor cells.
VLX600 inhibits a number of colon cancer cell lines with IC50 of 1 uM.
In KitV558del/+ mice, VLX600 alone did not induce tumor cell death, but had a profound antitumor effect when combined with imatinib.

物理化学性质&存储条件

分子量 317.356
分子式 C17H15N7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[1-(2-[6-Methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl]hydrazin-1-ylidene)ethyl]pyridine

参考文献

1. Zhang X, et al. Nat Commun. 2014;5:3295.

2. Fryknäs M, et al. Sci Rep. 2016 Dec 7;6:38343.

3. Antonescu CR, et al. Clin Cancer Res. 2018 Feb 15;24(4):972-984.

4. Karlsson H, et al. Oncotarget. 2019 Sep 3;10(51):5372-5382.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: