VKT-17-P4-23

Chemical Structure : VKT-17-P4-23

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货号: PC-28358Not For Human Use, Lab Use Only.

VKT-17-P4-23 is a small molecule inhibitor of Gram-negative bacteria DksA protein, inhibits DksA-mediated repression of rpsM in vitro transcription with IC50 of 72 nM, has MIC50 of 16 ug/mL against S. Typhimurium.

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生物&药学活性

VKT-17-P4-23 is a small molecule inhibitor of Gram-negative bacteria DksA protein, inhibits DksA-mediated repression of rpsM in vitro transcription with IC50 of 72 nM, has MIC50 of 16 ug/mL against S. Typhimurium.
VKT-17-P4-23 has microscale thermophoresis (MST) with a dissociation constant (Kd) of 124 μM, does not bind GreA and GreB.
VKT-17-P4-23 exerts antimicrobial activity, reduces the formation of intracellularly selected populations of Salmonella persistent cells.
VKT-17-P4-23 protects mice from the liver toxicity associated with Salmonella infection.
VKT-17-P4-23 exhibits antibiotic activity against Salmonella in gastrointestinal and systemic murine models of infection.

物理化学性质&存储条件

分子量	244.30
分子式	C13H16N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-phenylbutyl)-1H-1,2,4-triazole-3-carboxamide

参考文献

1. Kim JS, et al. Sci Adv. 2026 Mar 20;12(12):eaea6832.

VKT-17-P4-23

生物&药学活性

物理化学性质&存储条件

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VKT-17-P4-23

生物&药学活性

物理化学性质&存储条件

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