VK2809 (MB07811) | THRβ agonist | Probechem Biochemicals

Chemical Structure : VK2809

CAS No.: 852948-13-1

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VK2809 (VK-2809, MB-07811)

货号: PC-38030Not For Human Use, Lab Use Only.

VK2809 (VK-2809, MB-07811) is a potent, liver-specific thyroid hormone receptor β (THRβ) agonist for development for the treatment of hypercholesterolemia.

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5 mg	￥3580	In stock
10 mg	￥5480	In stock
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生物&药学活性

VK2809 (VK-2809, MB-07811) is a potent, liver-specific thyroid hormone receptor β (THRβ) agonist for development for the treatment of hypercholesterolemia.
VK2809 decreases hepatic triglyceride levels in GSD Ia mice through its simultaneous restoration of autophagy, mitochondrial biogenesis, and β-oxidation of fatty acids.
VK2809 (MB07811) is converted to MB07344 in liver microsomes.
VK2809 showed potent lipid lowering activity in the CFR (ED(50) 0.4 mg/kg, po) and good oral bioavailability (40%, rat).

物理化学性质&存储条件

分子量	514.983
分子式	C28H32ClO5P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	trans-(S)-2-[[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]methyl]-4-(3-chlorophenyl)-2-oxo-[1,3,2]dioxaphosphorinane

参考文献

1. Zhou J, et al. Thyroid. 2019 Aug;29(8):1158-1167.

2. Fujitaki JM, et al. Drug Metab Dispos. 2008 Nov;36(11):2393-403.

3. Boyer SH, et al. J Med Chem. 2008 Nov 27;51(22):7075-93.

VK2809 (VK-2809, MB-07811)

生物&药学活性

物理化学性质&存储条件

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VK2809 (VK-2809, MB-07811)

生物&药学活性

物理化学性质&存储条件

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