VK-II-86 | RyR2 inhibitor | Probechem Biochemicals

Chemical Structure : VK-II-86

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VK-II-86 (RyR2 inhibitor)

货号: PC-38485Not For Human Use, Lab Use Only.

VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).
VK-II-86 exhibited >2,000-fold lower beta-AR binding affinity than carvedilol.
VK-II-86 prevented stress-induced ventricular tachyarrhythmias in RyR2-mutant mice and did so more effectively when combined with either of the selective beta blockers metoprolol or bisoprolol.
VK-II-86 prevented hypokalaemia-induced AP prolongation and depolarization but did not alter AP parameters in normokalaemia.

物理化学性质&存储条件

分子量	420.5
分子式	C25H28N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(9H-Carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-2-butanol

参考文献

1. Zhou Q, et al. Nat Med. 2011 Jul 10;17(8):1003-9.

2. Gonano LA, et al. Circ J. 2018 Dec 25;83(1):41-51.

3. Robinson VM, et al. Br J Pharmacol. 2021 Dec 7. doi: 10.1111/bph.15775.