VK-II-36 | RyR2 inhibitor | Probechem Biochemicals

Chemical Structure : VK-II-36

CAS No.: 955371-66-1

加入收藏

VK-II-36 (RyR2 inhibitor)

货号: PC-38452Not For Human Use, Lab Use Only.

VK-II-36 is a carvedilol analogue that suppresses sarcoplasmic reticulum (SR) Ca(2+) release and does not block the β-receptor, via direct action on the cardiac ryanodine receptor type 2 (RyR2).

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3880	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

VK-II-36 is a carvedilol analogue that suppresses sarcoplasmic reticulum (SR) Ca(2+) release and does not block the β-receptor, via direct action on the cardiac ryanodine receptor type 2 (RyR2).
VK-II-36 effectively suppressed spontaneous intracellular Ca(2+) elevations (SCaEs) and eliminated TAs observed in both mouse and rabbit ventricles.
VK-II-36 inhibits ventricular tachyarrhythmias in intact mouse and rabbit ventricles by the suppression of SCaEs, independent of beta-blocking activity.

物理化学性质&存储条件

分子量	446.50
分子式	C26H26N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[(9H-Carbazol-4-yloxy)methyl]-4-[2-(2-methoxyphenoxy)ethyl]-3-morpholinone

参考文献

1. Maruyama M, et al. Heart Rhythm. 2013 Jan;10(1):101-7.

2. Shinohara T, et al. Heart Vessels. 2014 May;29(3):396-403.

VK-II-36 (RyR2 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

VK-II-36 (RyR2 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.