VK-1727 | Probechem Biochemicals

Chemical Structure : VK-1727

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VK-1727 (VK1727, VK 1727)

货号: PC-36124Not For Human Use, Lab Use Only.

VK-1727 (VK1727) is a small-molecule inhibitor of the DNA binding activity of EBNA1 (Epstein-Barr nuclear antigen1).

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

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生物&药学活性

VK-1727 (VK1727) is a small-molecule inhibitor of the DNA binding activity of EBNA1 (Epstein-Barr nuclear antigen1).
VK-1727 selectively inhibits proliferation of EBV-positive cells (C666-1 CC50=6.3 uM) but not similarly growing EBV-negative cells.
VK-1727 potently inhibits EBNA1-dependent OriP DNA replicationm without effect on EBNA1 protein expression in EBV-positive NPC cell line, C666-1.
VK-1727 significantly blocks EBV-positive tumor growth in vivo (10 mg/kg, intraperitoneally, TGI=88.3%), block EBV gene transcription and alter the cellular TGF-β signaling pathway in NPC tumor xenografts.

物理化学性质&存储条件

分子量	451.522
分子式	C29H25NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2-(1H-indol-6-yl)-3-((4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)ethynyl)benzoate

参考文献

1. Messick TE, et al. Sci Transl Med. 2019 Mar 6;11(482). pii: eaau5612. doi: 10.1126/scitranslmed.aau5612.

VK-1727 (VK1727, VK 1727)

生物&药学活性

物理化学性质&存储条件

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VK-1727 (VK1727, VK 1727)

生物&药学活性

物理化学性质&存储条件

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