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首页-小分子抑制剂&激动剂-Others-Other Targets-VIT-2763
VIT-2763

Chemical Structure : VIT-2763

CAS No.: 2095668-10-1

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VIT-2763 (Vamifeport, VIT2763)

货号: PC-73101Not For Human Use, Lab Use Only.

VIT-2763 (Vamifeport, VIT2763) is an oral small molecule inhibitor of ferroportin, inhibits hepcidin binding to ferroportin with IC50 of 9 nM, blocks iron efflux.

规格 价格 库存 数量
5 mg ￥2880 In stock
10 mg ￥4280 In stock
25 mg ￥7280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VIT-2763 (Vamifeport, VIT2763) is an oral small molecule inhibitor of ferroportin, inhibits hepcidin binding to ferroportin with IC50 of 9 nM, blocks iron efflux.
VIT-2763 triggers ubiquitination and subsequent internalization and degradation of ferroportin.
Orally dosed VIT-2763 (30 mg/kg) decreased decrease in serum iron induced by hepcidin in rodents.
VIT-2763 decreased serum iron and prevented liver iron loading in Hbbth3/+ mice.
VIT-2763 significantly corrected anemia and improved RBC parameters in Hbbth3/+ mice, improved the ineffective erythropoiesis in BM and spleen.
VIT-2763 reduced the formation of insoluble α-globin aggregates and improved the elimination of mitochondria in RBCs.
VIT-2763 decreased apoptosis and extended the life span, reduced hypoxia response of RBCs.

物理化学性质&存储条件

分子量 408.437
分子式 C21H21FN6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-((2-(1H-benzo[d]imidazol-2-yl)ethyl)amino)ethyl)-N-((3-fluoropyridin-2-yl)methyl)oxazole-4-carboxamide

参考文献

1. Manolova V, et al. J Clin Invest. 2019 Dec 9;130(1):491-506.

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