VISTA inhibitor B3

Chemical Structure : VISTA inhibitor B3

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货号: PC-24095Not For Human Use, Lab Use Only.

VISTA inhibitor B3 is a potent, small molecule inhibitor of V-domain Ig suppressor of T-cell activation (VISTA) with binding KD of 0.452 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

VISTA inhibitor B3 is a potent, small molecule inhibitor of V-domain Ig suppressor of T-cell activation (VISTA) with binding KD of 0.452 uM.
B3 promotes the release of cytokine IL-2 in Jurkat cells and induces VISTA degradation in HepG2 cells.
B3 exhibits favorable oral bioavailability in rats.
B3 (30, 60, and 120 mg/kg, p.o.) significantly inhibited tumor growth in mouse CT-26 subcutaneous transplant tumor model.

物理化学性质&存储条件

分子量	402.52
分子式	C25H27FN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3-(6-(4-fluorophenyl)-7-methyl-1H-benzo[d]imidazol-2-yl)benzyl)-N2,N2-dimethylethane-1,2-diamine

参考文献

1. Qi Z, et al. J Med Chem. 2025 Feb 27. doi: 10.1021/acs.jmedchem.4c02031.