VISTA inhibitor A4

Chemical Structure : VISTA inhibitor A4

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货号: PC-24096Not For Human Use, Lab Use Only.

VISTA inhibitor A4 is a potent small molecule inhibitor of VISTA (V-domain Ig suppressor of T cell activation) with binding KD of 0.49 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

VISTA inhibitor A4 is a potent small molecule inhibitor of VISTA (V-domain Ig suppressor of T cell activation) with binding KD of 0.49 uM.
A4 (0.1-5 uM) blocks the VISTA signaling pathway in PBMCs, enhances IFN-γ release, also restores TNF-α release, enhances the killing ability of PBMCs against tumor cells.
A4 significantly activated peripheral blood mononuclear cells (PBMCs) induced the release of cytokines such as IFN-γ and enhanced the cytotoxicity of PBMCs against tumor cells.
A4 displayed potent antitumor activity and synergized with PD-L1 antibody to enhance the therapeutic effect against cancer.

物理化学性质&存储条件

分子量	290.32
分子式	C14H18N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-(((2-hydroxyethyl)amino)methyl)-6-methoxypyrimidin-2-yl)amino)phenol

参考文献

1. Sun C, et al. J Med Chem. 2024 Mar 14;67(5):3590-3605.