VI-116 | VRAC inhibitor | Probechem Biochemicals

Chemical Structure : VI-116

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VI-116 (VI116)

货号: PC-38691Not For Human Use, Lab Use Only.

VI-116 is a potent and selective volume-regulated anion channel (VRAC) inhibitor, fully inhibits VRAC-mediated I- quenching with an IC50 of 1.27 uM in LN215 cells.

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生物&药学活性

VI-116 is a potent and selective volume-regulated anion channel (VRAC) inhibitor, fully inhibits VRAC-mediated I- quenching with an IC50 of 1.27 uM in LN215 cells.
VI-116 potently blocked endogenous VRAC activity in PC3, HT29 and HeLa cells in a dose-dependent manner.
VI-116 had no effect on intracellular calcium signaling up to 10 μM, which completely inhibited VRAC, and showed high selectivity for VRAC compared to ANO1 and ANO2.
VI-116 showed minimal effect on hERG K+ channel activity up to 10 μM.

物理化学性质&存储条件

分子量	458.422
分子式	C26H18O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,3'-((2-hydroxy-3-methoxyphenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

参考文献

1. Dongkyu Jeon, et al. Int J Mol Sci. 2022 May 5;23(9):5168.

VI-116 (VI116)

生物&药学活性

物理化学性质&存储条件

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VI-116 (VI116)

生物&药学活性

物理化学性质&存储条件

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